Multiple sclerosis represents a disease of the central nervous system. It characterizes with a severe inflammation to the system, and it affects men and women globally. Also known as MS, the disorder affects the nerve fibers and interrupts the communication between the brain and the body itself.
When developed, MS can lead to permanent nerve damage and body immobility. Presently, there is no existing cure for this disorder. However, one expert and professor might be on a journey to a medical breakthrough which will help treat Multiple Sclerosis once and for all.
Dr. Su Metcalfe founded a company called LIFNano, which focuses on finding cures for MS. The team of experts works on curing the condition by treating the immunity with meds.
A Cure for Multiple Sclerosis
Metcalfe and her team found that there is a tiny binary switch, in charge of managing the immune cells. The doctor is now working with a stem-cell particle known as LIF. This particle protects the body from harm and activates the immunity whenever there is a need for protection. In addition, LIF stem-cell particles keep the bodily tissues operative and the brain active and coordinated with the body organs’ performance.
With this, Su hopes to create a ‘double whammy’ environment, which reverses the autoimmunity, and helps the brain heal.
During her research, Su found that LIF has a lifespan of 20 minutes only before the body dissolves it. However, even this finding alone promises a great deal when it comes to finding an effective cure for MS.
What are Nanoparticles?
When LIF and nanoparticles are combined, they favor the body plenty, and especially in terms of health. In fact, nanoparticles are in charge of delivering LIF across the body.
As per Su, ‘the nanoparticle itself is a protective environment, and the enzymes that break it down can’t access it. You can also decorate the surface of the particles with antibodies, so it becomes a homing device that can target specific parts of the brain. So you get the right dose, in the right place, and at the right time.’
How Helpful is Nano-Medicine?
According to Dr. Metcalfe, ‘Nano-medicine is a new era, and big pharma has already entered this space to deliver drugs while trying to avoid the side effects. The quantum leap is to actually go into biologics and tap into the natural pathways of the body. We’re not using any drugs, we’re simply switching on the body’s own systems of self-tolerance and repair. There aren’t any side effects because all we’re doing is tipping the balance.
Auto-immunity happens when that balance has gone awry slightly, and we simply reset that. Once you’ve done that, it becomes self-sustaining and you don’t have to keep giving therapy, because the body has its balance back.’
In the future, Su expects to commit more to these findings and start clinical trials in 2020.
‘We’ve got everything we need in place to make the nanoparticles in a clinically compliant manner, it’s just a case of flicking the switch when we have the money. We’re looking at VCs and big pharma because they have a strong interest in this area. We’re doing all our pre-clinical work concurrently while bringing in the major funds the company needs to go forward in its own right. The immune cell is the only single cell in the body that is its own unity, so it functions alone.
It’s probably one of the most powerful cells in the body because it can kill you, and if you haven’t got it you die because you haven’t got it.’
And even though Dr. Metcalfe currently focuses on curing MS, her future findings will ‘lead into other major autoimmune disease areas.’